Representative illustration of the pathology found in the asthmatic
bronchus compared with a normal bronchus (upper right). Each section
demonstrates how the lumen is narrowed. Hypertrophy of the basement membrane,
mucus plugging, smooth muscle hypertrophy, and constriction contribute
(lower section). Inflammatory cells infiltrate, producing submucosal edema, and
epithelial desquamation fills the airway lumen with cellular debris and exposes
the airway smooth muscle to other mediators (upper left).
bronchus compared with a normal bronchus (upper right). Each section
demonstrates how the lumen is narrowed. Hypertrophy of the basement membrane,
mucus plugging, smooth muscle hypertrophy, and constriction contribute
(lower section). Inflammatory cells infiltrate, producing submucosal edema, and
epithelial desquamation fills the airway lumen with cellular debris and exposes
the airway smooth muscle to other mediators (upper left).
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